Investigating the role of specific genes on male reproduction in mice.
Official title: The roles of mouse Y chromosome Zfy genes in male reproduction.
Funded at University of Hawaii at Manoa · NIH-11192729 · Data updated 2026-11-12
This study is looking at how two genes in male mice affect sperm production and fertility, using special techniques to see how these genes work, and it's aimed at helping us understand more about male reproduction.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Hawaii at Manoa NIH-funded |
| Lab location | 1 site (Honolulu, United States) |
| Project start | January 1, 2025 |
| Project end | May 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $51,997 |
| NIH project number | 3R01HD114645-01S1 |
| Project ID | NIH-11192729 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals experiencing male infertility or related reproductive issues.
✕Less likely to help
Patients who are not male or those without fertility concerns may not benefit from this research.
What this research studies
This research focuses on understanding how two specific genes on the mouse Y chromosome, known as Zfy1 and Zfy2, influence male reproduction. The researchers will use genetically modified mice to observe the effects of these genes on sperm development and fertility. By analyzing the molecular mechanisms involved, they aim to uncover how these genes regulate spermatogenesis, which is the process of sperm formation. The study employs advanced techniques like RNA sequencing and CRISPR/Cas9 gene editing to achieve its goals.
Why it matters
Potential benefit: If successful, this research could lead to new insights into male fertility and potential treatments for infertility in humans.
How similar studies have gone: While the specific focus on Zfy genes is relatively novel, previous research has successfully explored the roles of other Y chromosome genes in reproduction.
Where this research is happening
-
University of Hawaii at Manoa
Honolulu, United States Active
Researchers
- Principal investigator: Ward, Monika a — University of Hawaii at Manoa
- Study coordinator: Ward, Monika a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.