Investigating the role of specific genes on male reproduction in mice.
Official title: The roles of mouse Y chromosome Zfy genes in male reproduction.
Funded at University of Hawaii at Manoa · NIH-11160585 · Data updated 2026-11-12
This study is looking at how two specific genes in male mice affect sperm production and fertility, using advanced tools to learn more about how these genes help in the development of sperm cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Hawaii at Manoa NIH-funded |
| Lab location | 1 site (Honolulu, United States) |
| Project start | August 5, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $502,340 |
| NIH project number | 5R01HD114645-02 |
| Project ID | NIH-11160585 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be males experiencing infertility issues related to genetic factors.
✕Less likely to help
Patients who are not male or those whose infertility is not linked to genetic causes may not benefit from this research.
What this research studies
This research focuses on understanding how two genes on the mouse Y chromosome, known as Zfy1 and Zfy2, influence male reproduction. The study aims to uncover the molecular mechanisms by which these genes regulate the development of sperm cells. Researchers will utilize advanced techniques, including RNA sequencing and CRISPR technology, to analyze the effects of these genes on sperm production and fertility. By studying genetically modified mice, the project seeks to provide insights into the essential functions of Zfy genes in spermatogenesis.
Why it matters
Potential benefit: If successful, this research could lead to new insights into male fertility and potential treatments for infertility in men.
How similar studies have gone: Previous research has shown promising results in understanding the roles of Y chromosome genes in reproduction, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Hawaii at Manoa
Honolulu, United States Active
Researchers
- Principal investigator: Ward, Monika a — University of Hawaii at Manoa
- Study coordinator: Ward, Monika a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.