Investigating the role of specific genes in the development of Barrett's esophagus
Official title: The Role of SOX2 and CDX2 in Barrett's Esophagus Development
Funded at Washington University · NIH-11055373 · Data updated 2026-11-12
This study is looking at how certain genes, SOX2 and CDX2, might play a role in the development of Barrett's esophagus, which can lead to esophageal cancer, using special mouse models and lab-grown tissues from patients to see how changes in these genes affect the esophagus.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | July 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $162,511 |
| NIH project number | 5K08DK139376-03 |
| Project ID | NIH-11055373 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who have been diagnosed with Barrett's esophagus or are at risk due to chronic acid reflux.
✕Less likely to help
Patients who do not have Barrett's esophagus or related gastrointestinal conditions may not benefit from this research.
What this research studies
This research focuses on understanding how the genes SOX2 and CDX2 contribute to the development of Barrett's esophagus, a condition that can lead to esophageal cancer. The study will utilize genetic mouse models and human patient-derived organoids to explore how changes in these genes affect the esophagus's structure and function. By examining the effects of disrupting and restoring these genes, the research aims to uncover critical mechanisms involved in Barrett's esophagus development and maintenance, particularly in response to bile acid exposure.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential therapies for preventing or treating Barrett's esophagus and its progression to cancer.
How similar studies have gone: Previous research has shown promising results in understanding the genetic factors involved in Barrett's esophagus, making this approach both relevant and potentially impactful.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Jin, Ramon — Washington University
- Study coordinator: Jin, Ramon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.