Investigating the role of specific genes in salivary gland cancer development
Official title: Role of CRTC1-MAML2 in Salivary Mucoepidermoid Carcinoma Pathobiology
Funded at H. Lee Moffitt Cancer Ctr & Res Inst · NIH-11064862 · Data updated 2026-11-12
This study is looking into how a specific gene change affects the growth of mucoepidermoid carcinoma, a common type of salivary gland cancer, to help create better ways to diagnose and treat patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | December 2, 2022 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $498,468 |
| NIH project number | 5R01DE030123-06 |
| Project ID | NIH-11064862 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with mucoepidermoid carcinoma or those at risk for developing salivary gland tumors.
✕Less likely to help
Patients with non-cancerous salivary gland conditions or those with other types of salivary gland tumors may not benefit from this research.
What this research studies
This research focuses on understanding the molecular mechanisms behind mucoepidermoid carcinoma (MEC), the most common malignant tumor of the salivary glands. By examining the CRTC1-MAML2 fusion oncogene, which is present in over 50% of MEC cases, the study aims to uncover how this genetic alteration influences tumor growth and differentiation. The research employs advanced techniques to analyze gene expression and signaling pathways, which could lead to the development of new diagnostic tools and therapies for patients with this type of cancer.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and outcomes for patients suffering from salivary gland cancer.
How similar studies have gone: Previous research has shown promising results in understanding the genetic basis of other cancers, suggesting that this approach could yield valuable insights for mucoepidermoid carcinoma as well.
Where this research is happening
-
H. Lee Moffitt Cancer Ctr & Res Inst
Tampa, United States Active
Researchers
- Principal investigator: Amelio, Antonio Luigi — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Amelio, Antonio Luigi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.