Investigating the role of specific enzymes in heart failure
Roles of Histone lysine demethylases KDM5A and KDM5B in the pathogenesis of Heart failure
This study is looking at how specific enzymes in the heart might play a role in heart failure, especially when there are genetic factors involved, and it hopes to find new ways to help people with heart failure by testing these ideas in mice.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10937671 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain enzymes, known as histone lysine demethylases KDM5A and KDM5B, contribute to the development of heart failure. By examining changes in gene expression and epigenetic modifications in heart tissue, the study aims to uncover the mechanisms behind heart failure, particularly in cases linked to genetic mutations. The research utilizes mouse models to explore how manipulating these enzymes affects heart function and overall survival. Patients may benefit from insights that could lead to new therapeutic strategies for heart failure.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with hereditary cardiomyopathies or those experiencing heart failure symptoms.
Not a fit: Patients with heart failure not linked to genetic factors or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and survival rates for patients with heart failure.
How similar studies have performed: Other research has shown promising results in understanding the role of epigenetic factors in heart disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Gurha, Priyatansh — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Gurha, Priyatansh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.