Investigating the role of specific enzymes in heart failure
Official title: Roles of Histone lysine demethylases KDM5A and KDM5B in the pathogenesis of Heart failure
Funded at University of Texas Hlth Sci Ctr Houston · NIH-10937671 · Data updated 2026-11-12
This study is looking at how specific enzymes in the heart might play a role in heart failure, especially when there are genetic factors involved, and it hopes to find new ways to help people with heart failure by testing these ideas in mice.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $601,563 |
| NIH project number | 1R01HL174481-01 |
| Project ID | NIH-10937671 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults with hereditary cardiomyopathies or those experiencing heart failure symptoms.
✕Less likely to help
Patients with heart failure not linked to genetic factors or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on understanding how certain enzymes, known as histone lysine demethylases KDM5A and KDM5B, contribute to the development of heart failure. By examining changes in gene expression and epigenetic modifications in heart tissue, the study aims to uncover the mechanisms behind heart failure, particularly in cases linked to genetic mutations. The research utilizes mouse models to explore how manipulating these enzymes affects heart function and overall survival. Patients may benefit from insights that could lead to new therapeutic strategies for heart failure.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and survival rates for patients with heart failure.
How similar studies have gone: Other research has shown promising results in understanding the role of epigenetic factors in heart disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Gurha, Priyatansh — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Gurha, Priyatansh
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.