Investigating the role of specific enzymes in heart development and disease
Role of cardiac m6A methyltransferases
This study is looking at how certain enzymes affect heart development in unborn babies and could help us understand why some babies develop dilated cardiomyopathy, a heart condition, so that we can learn more about the genetic factors involved.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-11023194 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain enzymes, known as m6A methyltransferases, influence heart development and the onset of dilated cardiomyopathy (DCM) in fetuses. By using mouse models, the researchers will explore how these enzymes affect the processing and stability of heart-related genes during early development. The study aims to fill a critical knowledge gap regarding the genetic and molecular factors contributing to early-onset DCM, which is often linked to genetic mutations. Through advanced techniques in biochemistry and molecular biology, the research seeks to uncover the mechanisms behind heart muscle cell function and potential dysregulation in disease.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include infants diagnosed with early-onset dilated cardiomyopathy or those with a family history of cardiac conditions.
Not a fit: Patients with non-cardiac related conditions or those who are not within the early-onset DCM spectrum may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapeutic strategies for preventing or treating early-onset dilated cardiomyopathy in infants.
How similar studies have performed: Previous research has shown that targeting post-transcriptional regulation can be effective in understanding and treating cardiac conditions, suggesting a promising avenue for this investigation.
Where this research is happening
Columbus, United States
- Research Inst Nationwide Children's Hosp — Columbus, United States (Active)
Researchers
- Principal investigator: Jang, Jihyun — Research Inst Nationwide Children's Hosp
- Study coordinator: Jang, Jihyun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.