Investigating the role of specific cells in gut development and health
Official title: FOXL1 positive telocytes in intestinal development and homeostsis
Funded at University of Pennsylvania · NIH-11084408 · Data updated 2026-11-12
This study is looking at special cells in the gut called FOXL1 positive telocytes to see how they help keep the intestinal lining healthy and support the cells that renew it, which could lead to new treatments for gut problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | May 15, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $541,989 |
| NIH project number | 5R01DK139049-02 |
| Project ID | NIH-11084408 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with gastrointestinal disorders or those interested in the biological mechanisms of gut health.
✕Less likely to help
Patients with non-intestinal related health issues or those outside the age range of 21+ years may not receive direct benefits from this research.
What this research studies
This research focuses on understanding how FOXL1 positive telocytes contribute to the development and maintenance of the intestinal lining. By examining these specialized cells, the study aims to uncover their role in supporting intestinal stem cells, which are crucial for the continuous renewal of the gut epithelium. The researchers will use advanced techniques, including genetic manipulation and single-cell analysis, to explore how these cells influence gut health and development, particularly during critical growth periods. Patients may benefit from insights gained about intestinal disorders and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for intestinal diseases by enhancing our understanding of gut cell biology.
How similar studies have gone: Previous research has shown promising results in understanding the role of stem cells in intestinal health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Kaestner, Klaus H — University of Pennsylvania
- Study coordinator: Kaestner, Klaus H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.