Investigating the role of specific brain cells in autism and related disorders
Official title: Cellular and circuit function of Ndnf-expressing interneurons in a mouse model of a neurodevelopmental disorder
Funded at University of Pennsylvania · NIH-11127673 · Data updated 2026-11-12
This study is looking at special brain cells that might play a role in autism, using mice to see how these cells work and what happens when they don’t function properly, with the hope of finding new ways to help people with autism.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31NS132519-03 |
| Project ID | NIH-11127673 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are diagnosed with autism spectrum disorder or related neurodevelopmental conditions.
✕Less likely to help
Patients who are older than 11 years or do not have a diagnosis of a neurodevelopmental disorder may not benefit from this research.
What this research studies
This research focuses on understanding how a specific type of brain cell, known as Ndnf-expressing interneurons, functions in the context of neurodevelopmental disorders like autism. Using a mouse model, the researchers will explore how these cells contribute to brain circuit activity and how their dysfunction may lead to symptoms associated with autism. The study employs advanced imaging techniques to observe these cells in action, aiming to uncover the underlying mechanisms that could inform future therapies. By gaining insights into these brain cells, the research seeks to enhance our understanding of autism and related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating autism and other neurodevelopmental disorders.
How similar studies have gone: Previous research has shown promising results in understanding the role of different brain cell types in neurodevelopmental disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Liebergall, Sophie Rose — University of Pennsylvania
- Study coordinator: Liebergall, Sophie Rose
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.