Investigating the role of specific B cells in rheumatoid arthritis
Official title: Role of T-bet B cells in rheumatoid arthritis
Funded at University of Rochester · NIH-11000379 · Data updated 2026-11-12
This study is looking at specific types of B cells in people with rheumatoid arthritis to see how they might be causing inflammation and damage to bones, with the hope of finding new ways to help manage the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | December 12, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $683,909 |
| NIH project number | 5R01AI175212-02 |
| Project ID | NIH-11000379 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with rheumatoid arthritis who experience persistent inflammation and joint damage despite current treatments.
✕Less likely to help
Patients with rheumatoid arthritis who are in complete remission or have mild disease may not benefit from this research.
What this research studies
This research focuses on understanding how certain B cell subsets, particularly those expressing the T-bet transcription factor, contribute to the ongoing inflammation and bone damage seen in rheumatoid arthritis (RA). By examining these B cells in the synovial tissue of RA patients, the researchers aim to uncover their role in promoting bone erosion and inhibiting bone formation. The study utilizes advanced techniques to analyze the interactions between B cells and other immune cells, which could lead to new therapeutic targets for managing RA.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments that reduce inflammation and prevent joint damage in rheumatoid arthritis patients.
How similar studies have gone: Previous research has shown promising results in targeting specific immune cell subsets in autoimmune diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Anolik, Jennifer Howitt — University of Rochester
- Study coordinator: Anolik, Jennifer Howitt
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.