Investigating the role of specific B cells in pancreatic cancer
Official title: Function of IL35+ B cells in pancreatic cancer
Funded at Univ of North Carolina Chapel Hill · NIH-11066558 · Data updated 2026-11-12
This study is looking at how certain immune cells called B cells help pancreatic cancer grow, and it aims to find new ways to improve treatments for patients with this type of cancer.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $417,022 |
| NIH project number | 5R37CA230786-07 |
| Project ID | NIH-11066558 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with pancreatic ductal adenocarcinoma who may benefit from novel immunotherapy approaches.
✕Less likely to help
Patients with other types of cancer or those who do not have pancreatic cancer may not receive any benefit from this research.
What this research studies
This research focuses on understanding how B cells that produce the cytokine IL35 contribute to the growth of pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC). The study will explore the mechanisms by which these B cells create an environment that supports tumor growth and how targeting this pathway could enhance existing immunotherapies. By using mouse models, researchers will analyze the interactions between B cells and tumor cells, aiming to identify new therapeutic strategies that could improve treatment outcomes for patients with PDAC.
Why it matters
Potential benefit: If successful, this research could lead to new immunotherapy strategies that improve survival rates for patients with pancreatic cancer.
How similar studies have gone: Previous research has shown promise in targeting immune cells in cancer therapy, suggesting that this approach may yield significant insights and advancements.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Pylayeva-Gupta, Yuliya — Univ of North Carolina Chapel Hill
- Study coordinator: Pylayeva-Gupta, Yuliya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.