Investigating the role of SOX8 in muscle development and a type of childhood cancer.
Official title: Determining the Role of SOX8 in Myogenesis and Rhabdomyosarcomagenesis
Funded at St. Jude Children's Research Hospital Graduate School of Biomedical Sciences, LLC · NIH-11019687 · Data updated 2026-11-12
This study is looking at how a gene called SOX8 affects muscle growth and its connection to rhabdomyosarcoma, a serious cancer that affects kids, to find new ways to help treat young patients with this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital Graduate School of Biomedical Sciences, LLC NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $48,538 |
| NIH project number | 5F31CA281254-02 |
| Project ID | NIH-11019687 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children diagnosed with rhabdomyosarcoma or those at risk for developing this type of cancer.
✕Less likely to help
Patients with other types of cancers or those who are not diagnosed with rhabdomyosarcoma may not benefit from this research.
What this research studies
This research focuses on understanding how the SOX8 gene influences muscle development and its potential link to rhabdomyosarcoma, a common and aggressive cancer in children. By studying the effects of SOX8 in both laboratory cultures and genetically engineered mouse models, the researchers aim to uncover new insights into the biology of this cancer. The project seeks to identify new molecular targets that could lead to improved treatments for pediatric patients suffering from rhabdomyosarcoma.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies that improve survival rates and reduce long-term treatment-related consequences for children with rhabdomyosarcoma.
How similar studies have gone: Other research has shown promise in targeting molecular pathways in childhood cancers, suggesting that this approach could yield valuable insights.
Where this research is happening
-
St. Jude Children's Research Hospital Graduate School of Biomedical Sciences, LLC
Memphis, United States Active
Researchers
- Principal investigator: Stevens, Bradley — St. Jude Children's Research Hospital Graduate School of Biomedical Sciences, LLC
- Study coordinator: Stevens, Bradley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.