Investigating the role of SOX4 in esophageal adenocarcinoma development
Official title: SOX4-Mediated Transcription Program in Esophageal Adenocarcinoma
Funded at University of Miami School of Medicine · NIH-10866612 · Data updated 2026-11-12
This study is looking at how a gene called SOX4 affects the development of esophageal adenocarcinoma, a type of cancer that is becoming more common, to find new ways to treat patients who have it, especially those with Barrett's esophagus caused by long-term acid reflux.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | July 8, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $384,175 |
| NIH project number | 5P01CA268991-03 |
| Project ID | NIH-10866612 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Barrett's esophagus or esophageal adenocarcinoma, particularly those with a history of chronic acid reflux.
✕Less likely to help
Patients with other types of esophageal cancer or those without a history of Barrett's esophagus may not benefit from this research.
What this research studies
This research focuses on understanding how the SOX4 gene influences the development of esophageal adenocarcinoma (EAC), a type of cancer that has seen a dramatic increase in incidence. By exploring the molecular mechanisms that lead to the transformation of stem cells into cancerous cells, the study aims to identify new therapeutic targets that could improve treatment options for patients. The research involves analyzing the effects of prolonged acid reflux and specific genetic changes on the development of Barrett's esophagus, a precursor to EAC. Patients may benefit from insights gained that could lead to innovative treatments for this aggressive cancer.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve survival rates for patients with esophageal adenocarcinoma.
How similar studies have gone: Previous research has shown promising results in targeting molecular mechanisms in cancer, suggesting that this approach could yield significant advancements in treatment.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Que, Jianwen — University of Miami School of Medicine
- Study coordinator: Que, Jianwen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.