Investigating the role of SNX19 in aging brains and Alzheimer's disease
Official title: The role of SNX19 in aging brains at single cell resolution and cerebral organoids
Funded at University of Texas Hlth Science Center · NIH-10984597 · Data updated 2026-11-12
This study is looking at how a protein called SNX19 might play a role in aging brains and Alzheimer's disease, using brain samples and lab-grown brain cells to find out more, with the hope of discovering new ways to help people with Alzheimer's.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $118,557 |
| NIH project number | 1K01AG084813-01A1 |
| Project ID | NIH-10984597 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a genetic predisposition to Alzheimer's disease, particularly those carrying the APOE ε4 allele.
✕Less likely to help
Patients with non-neurodegenerative conditions or those without a family history of Alzheimer's disease may not receive benefit from this research.
What this research studies
This research focuses on understanding how the SNX19 protein affects aging brains and contributes to Alzheimer's disease and related dementias. By examining postmortem brain tissue at a single-cell level and using human-derived brain organoids, the study aims to uncover the mechanisms linking SNX19 to neurodegenerative processes. The approach includes advanced techniques like single molecule in situ hybridization and RNA sequencing to analyze gene expression and its association with Alzheimer's-related pathologies. Patients may benefit from insights that could lead to new treatment strategies for Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for treating Alzheimer's disease and improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding neurodegenerative diseases through similar cellular and molecular approaches, suggesting potential for success in this area.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Ma, Liang — University of Texas Hlth Science Center
- Study coordinator: Ma, Liang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.