Investigating the role of SLURP1 in eye inflammation
Ocular surface functions of SLURP1
This study is looking at a protein called SLURP1 in the eye to see how it helps control inflammation, which could lead to better treatments for common eye problems like dry eye disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10897729 on NIH RePORTER |
What this research studies
This research focuses on understanding how SLURP1, a protein found in the eye, helps regulate inflammation on the ocular surface. By examining its effects on immune responses and cell signaling, the study aims to uncover new therapeutic strategies for treating inflammatory eye conditions. The researchers will conduct experiments to see how SLURP1 influences the behavior of immune cells and the formation of blood vessels in the cornea, which are critical in conditions like dry eye disease. Patients may benefit from insights gained that could lead to improved treatments for common eye disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing inflammatory eye conditions, such as dry eye syndrome or other related disorders.
Not a fit: Patients with non-inflammatory eye conditions or those not experiencing ocular surface issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that alleviate symptoms and improve the quality of life for patients suffering from inflammatory eye diseases.
How similar studies have performed: Previous studies have shown promise in targeting similar immunomodulatory pathways, suggesting that this approach could yield significant advancements in treatment.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Swamynathan, Shivalingappa Kottur — University of South Florida
- Study coordinator: Swamynathan, Shivalingappa Kottur
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.