Investigating the role of SIRT5 in Acute Myeloid Leukemia
Targeting the Metabolic Regulator SIRT5 in Acute Myeloid Leukemia
This study is looking at how a specific protein called SIRT5 influences Acute Myeloid Leukemia (AML) to find new ways to treat this tough blood cancer and help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Versiti Wisconsin, INC. NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-10886567 on NIH RePORTER |
What this research studies
This research focuses on understanding how the metabolic regulator SIRT5 affects Acute Myeloid Leukemia (AML), a type of aggressive blood cancer. The study aims to identify new therapeutic targets by examining primary AML cells in conditions that mimic the bone marrow environment. By using advanced techniques like shRNA screening, researchers hope to uncover vulnerabilities in AML cells that could lead to more effective treatments. The goal is to find ways to overcome the limitations of current therapies and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Acute Myeloid Leukemia who may benefit from novel therapeutic approaches.
Not a fit: Patients with other types of leukemia or those who do not have a diagnosis of Acute Myeloid Leukemia may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that are more effective for patients with Acute Myeloid Leukemia.
How similar studies have performed: Other research has shown promise in targeting metabolic regulators in cancer, suggesting that this approach could be effective in AML as well.
Where this research is happening
Milwaukee, United States
- Versiti Wisconsin, INC. — Milwaukee, United States (Active)
Researchers
- Principal investigator: Deininger, Michael W. — Versiti Wisconsin, INC.
- Study coordinator: Deininger, Michael W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.