Investigating the role of SETD1A mutations in brain disorders
Loss-of-Function Analyses of SETD1A in Human Neural Models
This study is looking at how rare changes in a specific gene might be connected to schizophrenia and similar conditions, using special brain cells created from people’s skin cells to better understand how these changes affect brain function and could lead to new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11081029 on NIH RePORTER |
What this research studies
This research focuses on understanding how rare mutations in the SETD1A gene are linked to schizophrenia and other neurodevelopmental disorders. By using human induced pluripotent stem cells (hiPSCs) and advanced gene editing techniques, the study aims to recreate the effects of these mutations in brain cells. The researchers will analyze changes in gene expression and cellular behavior to uncover the underlying mechanisms that contribute to these mental health conditions. This approach could provide insights into the biological processes involved in schizophrenia and help identify potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a diagnosis of schizophrenia or those with family histories of neurodevelopmental disorders linked to SETD1A mutations.
Not a fit: Patients without any genetic predisposition to schizophrenia or related neurodevelopmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments or interventions for schizophrenia and related disorders.
How similar studies have performed: Previous research has shown promising results in understanding the genetic basis of schizophrenia through similar methodologies, indicating potential for success in this study.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Pang, Zhiping P. — Rutgers Biomedical and Health Sciences
- Study coordinator: Pang, Zhiping P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.