Investigating the role of Sertad4 in heart failure and cardiac remodeling.
The role of Sertad4 in pathologic cardiac remodeling.
This study is looking at a protein called Sertad4 to see how it affects heart failure, especially after heart attacks, and aims to find new ways to help keep hearts healthy by possibly blocking this protein.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10861028 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific protein, Sertad4, contributes to heart failure, a condition affecting millions of Americans. The team aims to identify new therapeutic targets by studying Sertad4's role in activating harmful gene expression in heart cells, particularly after heart attacks. By using advanced techniques, they will explore whether inhibiting Sertad4 can help maintain heart function and prevent further damage. This approach seeks to improve treatment strategies that have previously failed in human trials.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure or those who have experienced a myocardial infarction.
Not a fit: Patients with heart conditions unrelated to cardiac remodeling or those who do not have heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better preserve heart function and improve survival rates for patients with heart failure.
How similar studies have performed: While there have been successful studies targeting other proteins in heart failure, the specific focus on Sertad4 is relatively novel and untested in this context.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Stratton, Matthew — Ohio State University
- Study coordinator: Stratton, Matthew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.