Investigating the role of SERPINE family genes in aggressive tumors
SERPINE family genes in rhabdoid tumorigenesis
This study is looking at how certain aggressive features in kidney tumors, specifically clear cell renal cell carcinoma, work at a molecular level, with the goal of finding better ways to diagnose and treat patients with these types of tumors.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11036091 on NIH RePORTER |
What this research studies
This research focuses on understanding the molecular mechanisms behind rhabdoid features in tumors, particularly in clear cell renal cell carcinoma (ccRCC). The study aims to improve diagnostic accuracy and treatment strategies by analyzing biopsy specimens and utilizing advanced multi-omics data. Researchers will employ computational and experimental methods to identify the genetic signatures associated with these aggressive tumor features. By uncovering these mechanisms, the research seeks to provide insights that could lead to better management of patients with rhabdoid tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with clear cell renal cell carcinoma exhibiting rhabdoid features.
Not a fit: Patients with other types of tumors that do not exhibit rhabdoid features may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and treatment options for patients with aggressive tumors characterized by rhabdoid features.
How similar studies have performed: While the specific focus on SERPINE family genes in rhabdoid tumors is novel, similar approaches in understanding tumor biology have shown promise in other cancer types.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Li, Yize — Washington University
- Study coordinator: Li, Yize
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.