Investigating the role of serotonin receptors in Alzheimer's disease symptoms
Official title: 5-HT 2C Receptor and Alzheimer's Disease
Funded at Baylor College of Medicine · NIH-10928224 · Data updated 2026-11-12
This study is looking at how a specific serotonin receptor might affect behaviors like aggression and social interactions in Alzheimer's disease, using a mouse model that reflects some genetic changes seen in people with the condition, to find new ways to help improve the lives of those living with Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $558,372 |
| NIH project number | 5R01AG080392-02 |
| Project ID | NIH-10928224 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease who exhibit neuropsychiatric symptoms such as aggression or social withdrawal.
✕Less likely to help
Patients with Alzheimer's disease who do not exhibit neuropsychiatric symptoms may not benefit from this research.
What this research studies
This research focuses on understanding how serotonin receptors, specifically the 5-HT 2C receptor, are involved in the neuropsychiatric symptoms of Alzheimer's disease (AD), such as aggression and impaired sociability. The study utilizes a mouse model that mimics genetic mutations found in humans with cognitive deficits to explore the effects of serotonin signaling on behavior and memory. By examining these mechanisms, the research aims to identify potential therapeutic targets for improving the quality of life for AD patients. The approach includes both genetic analysis and behavioral assessments in the mouse model.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate neuropsychiatric symptoms in Alzheimer's patients, improving their overall care and quality of life.
How similar studies have gone: Previous research has indicated that targeting serotonin signaling may improve symptoms in neuropsychiatric disorders, suggesting potential success for this novel approach in Alzheimer's disease.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Xu, Yong — Baylor College of Medicine
- Study coordinator: Xu, Yong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.