Investigating the role of serotonin in mood changes related to Alzheimer's disease
Serotonergic IL-1R1 and Neuropsychiatric Traits of an Alzheimer's Mouse Model
This study is looking at how Alzheimer's disease impacts not just memory but also feelings and behaviors like anxiety and depression, and it's specifically checking out a brain receptor that might help us find new ways to treat these mood issues in people with Alzheimer's.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida Atlantic University NIH-funded |
| Lab location | 1 site (Boca Raton, United States) |
| Project ID | NIH-10452857 on NIH RePORTER |
What this research studies
This research explores how Alzheimer's disease affects not only memory but also mood and behavior, such as anxiety and depression. It focuses on the role of a specific receptor, IL-1R1, that interacts with serotonin-producing neurons in the brain. By studying a mouse model of Alzheimer's, the researchers aim to understand how inflammation and serotonin levels are linked to these neuropsychiatric traits. The goal is to uncover mechanisms that could lead to new treatments for mood disorders associated with Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease who also experience mood-related symptoms such as anxiety or depression.
Not a fit: Patients with Alzheimer's disease who do not exhibit any mood-related symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing mood disorders in Alzheimer's patients.
How similar studies have performed: While the specific approach of this research is novel, previous studies have indicated a connection between serotonin and mood disorders in Alzheimer's, suggesting potential for success.
Where this research is happening
Boca Raton, United States
- Florida Atlantic University — Boca Raton, United States (Active)
Researchers
- Principal investigator: Blakely, Randy D. — Florida Atlantic University
- Study coordinator: Blakely, Randy D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.