Investigating the role of senescent cells in aging and age-related diseases
Core D - Senescence Molecular Phenotyping Core (SMPC)
This study is looking at how certain aging cells behave in our bodies and hopes to find ways to target them, which could lead to better treatments for age-related health issues that many people face.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11079505 on NIH RePORTER |
What this research studies
This research focuses on understanding cellular senescence, which is a significant factor in aging and related diseases. The team aims to identify and characterize specific sub-populations of senescent cells in various tissues using advanced technologies like single-cell RNA sequencing and multi-plex imaging. By studying these cells, the research seeks to explore how targeting them can influence aging processes and improve health outcomes. Patients may benefit from insights that could lead to new therapeutic strategies for age-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related diseases or conditions.
Not a fit: Patients who are not elderly or do not have age-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that slow down aging and improve health in older adults.
How similar studies have performed: Previous research has shown promising results in targeting senescent cells, indicating potential for success in this area.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Passos, Joao — Mayo Clinic Rochester
- Study coordinator: Passos, Joao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.