Investigating the role of RSPO2-LGR4 signaling in the development of atherosclerosis
Official title: RSPO2-LGR4 signaling in atherosclerosis
Funded at University of Tennessee Health Sci Ctr · NIH-11048941 · Data updated 2026-11-12
This study is looking at how certain cells in your blood vessels affect heart disease and plaque buildup, and it aims to find new ways to help prevent or treat atherosclerosis, which is important for keeping your heart healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | January 6, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $559,893 |
| NIH project number | 1R01HL172809-01A1 |
| Project ID | NIH-11048941 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for atherosclerosis, including those with cardiovascular disease or related risk factors.
✕Less likely to help
Patients who do not have any cardiovascular risk factors or existing atherosclerotic conditions may not benefit from this research.
What this research studies
This research focuses on understanding how vascular smooth muscle cells (VSMCs) contribute to atherosclerosis, a condition that leads to heart disease. By using advanced techniques like single-cell RNA sequencing and genetic approaches, the study aims to uncover the mechanisms by which these cells influence other arterial cells and contribute to plaque formation. The research also explores the role of the lymphatic system in cholesterol removal and inflammation in arteries, which is crucial for preventing atherosclerosis. Ultimately, the goal is to identify new therapeutic targets that could help manage or prevent this disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce the risk of atherosclerosis and related cardiovascular diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of vascular smooth muscle cells in atherosclerosis, indicating that this approach has potential for success.
Where this research is happening
-
University of Tennessee Health Sci Ctr
Memphis, United States Active
Researchers
- Principal investigator: Singla, Bhupesh — University of Tennessee Health Sci Ctr
- Study coordinator: Singla, Bhupesh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.