Investigating the role of ROS1 gene changes in cancer treatment
Functional impact, mechanistic role, and targetability of ROS1 aberrations in cancer
This study is looking at how changes in the ROS1 gene can lead to cancer and how we can use that information to create better treatments, especially for patients with ROS1-related cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10789926 on NIH RePORTER |
What this research studies
This research focuses on understanding how changes in the ROS1 gene contribute to cancer development and how these changes can be targeted for treatment. By studying specific mutations in the ROS1 gene, researchers aim to determine their effects on cancer progression and response to targeted therapies. The project will involve laboratory experiments to explore the mechanisms by which ROS1 mutations influence cancer behavior and treatment outcomes. Patients with ROS1-related cancers may benefit from insights gained through this research, potentially leading to more effective therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with cancers that have ROS1 gene alterations.
Not a fit: Patients whose cancers do not involve ROS1 mutations are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with ROS1-positive cancers.
How similar studies have performed: Previous research has shown promising results in targeting ROS1 mutations with specific therapies, indicating a potential for success in this area.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Davare, Monika a — Oregon Health & Science University
- Study coordinator: Davare, Monika a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.