Investigating the role of RNAs on the surface of neutrophils
The role of cell surface RNAs in neutrophils
This study is looking at special molecules on the surface of immune cells called neutrophils to see how they help these cells move from the blood into tissues, which is important for fighting inflammation and healing, and it could help us find new ways to improve immune responses in different health conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10984992 on NIH RePORTER |
What this research studies
This research explores the presence and function of glycosylated RNAs, known as glycoRNAs, on the surface of neutrophils, which are key immune cells involved in inflammation and tissue repair. The study aims to understand how these surface RNAs influence neutrophil interactions with blood vessel cells, which is crucial for their movement from the bloodstream into tissues. By examining the mechanisms behind these interactions, the research seeks to uncover new insights into neutrophil behavior and their role in immune responses. This could lead to a better understanding of how to modulate immune responses in various conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions involving inflammation or immune system dysfunction.
Not a fit: Patients with stable, non-inflammatory conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for enhancing or regulating immune responses in inflammatory diseases.
How similar studies have performed: While the investigation of glycoRNAs is a relatively novel approach, similar studies on cell surface molecules have shown promise in understanding immune cell functions.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Lu, Jun — Yale University
- Study coordinator: Lu, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.