Investigating the role of REST in Alzheimer's disease
Targeting REST in Alzheimer's Disease
This study is looking at how a protein called REST affects brain health and inflammation in Alzheimer's disease, using specially modified mice to find ways to protect brain cells and improve thinking skills for people with Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11089503 on NIH RePORTER |
What this research studies
This research focuses on understanding how the REST transcription factor affects brain function and inflammation in Alzheimer's disease (AD). By studying genetically modified mice, the researchers aim to uncover how REST influences neural networks and microglial activity, which are critical in the progression of AD. The project seeks to develop new therapeutic strategies that could protect neurons from damage and improve cognitive function in individuals with AD. Through this work, the team hopes to identify potential interventions that could slow down or reverse the effects of Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those experiencing mild cognitive impairment.
Not a fit: Patients with advanced Alzheimer's disease or those with other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve memory and cognitive function in patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in Alzheimer's disease, suggesting potential for success in this novel approach.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Yankner, Bruce a — Harvard Medical School
- Study coordinator: Yankner, Bruce a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.