Investigating the role of reactive sulfur species in health and disease
Official title: Explore the Chemistry and Chemical Biology of Reactive Sulfur Species
Funded at Brown University · NIH-11057671 · Data updated 2026-11-12
This study is looking at special sulfur compounds that are important for our health and can affect diseases, and it aims to find new ways to create and detect these compounds to help improve diagnosis and treatment options for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | May 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $358,904 |
| NIH project number | 5R35GM149170-03 |
| Project ID | NIH-11057671 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions influenced by redox biology and reactive sulfur species.
✕Less likely to help
Patients with diseases unrelated to redox biology or reactive sulfur species may not benefit from this research.
What this research studies
This research focuses on understanding reactive sulfur species (RSS) such as hydrogen sulfide and polysulfides, which play important roles in biological processes and disease states. The research team will explore new chemical compounds that can donate these sulfur species and study their interactions with proteins. They will also develop advanced fluorescent dyes to detect these species in biological systems. By uncovering the mechanisms of action of RSS, this research aims to pave the way for new diagnostic and therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to innovative diagnostic tools and treatments for various diseases linked to reactive sulfur species.
How similar studies have gone: Previous research has shown promising results in understanding the biological roles of reactive sulfur species, indicating potential for success in this area.
Where this research is happening
-
Brown University
Providence, United States Active
Researchers
- Principal investigator: Xian, Ming — Brown University
- Study coordinator: Xian, Ming
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.