Investigating the role of Rasa1 in blood vessel development
Role of Rasa1 in embryonic development
This study is looking at how changes in the Rasa1 gene can cause problems with blood and lymph vessels during early development, which is important for understanding conditions like capillary malformation-arteriovenous malformation syndrome that can lead to serious health issues, and it aims to find ways to help those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11177072 on NIH RePORTER |
What this research studies
This research focuses on understanding how mutations in the Rasa1 gene affect the development of blood and lymphatic vessels during embryonic growth. It examines the genetic basis of vascular anomalies, particularly capillary malformation-arteriovenous malformation (CM-AVM) syndrome, which can lead to serious health issues such as brain arteriovenous malformations and lymphatic anomalies. By using animal models, the research aims to uncover the mechanisms by which Rasa1 mutations disrupt normal vascular development and contribute to these conditions. The findings could provide insights into potential therapeutic strategies for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with congenital vascular anomalies, particularly those diagnosed with CM-AVM syndrome.
Not a fit: Patients without genetic mutations related to vascular development or those with unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with vascular and lymphatic anomalies.
How similar studies have performed: Previous research has shown success in understanding genetic contributions to vascular anomalies, but the specific role of Rasa1 in human conditions remains less explored.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Lawson, Nathan D — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Lawson, Nathan D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.