Investigating the role of RAGE and mitochondria in Alzheimer's disease
RAGE, mitochondria, and tau pathology in AD
This study is looking at how a specific receptor called RAGE affects the energy-producing parts of brain cells and may play a role in the memory problems seen in Alzheimer's disease, using samples from both the brain and blood to better understand what's happening in the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10532703 on NIH RePORTER |
What this research studies
This research focuses on understanding how the RAGE receptor affects mitochondrial function and contributes to the pathology of Alzheimer's disease (AD). It aims to explore the relationship between RAGE, oxidative stress, and synaptic dysfunction in the brains of individuals with AD. By examining the impact of RAGE on mitochondrial structure and function, the study seeks to uncover potential mechanisms that lead to cognitive decline in Alzheimer's patients. The research will involve both brain tissue and peripheral samples, such as platelets, to provide a comprehensive view of the disease's effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those exhibiting early signs of cognitive decline.
Not a fit: Patients with other forms of dementia or cognitive impairment unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that restore mitochondrial function and improve cognitive outcomes for Alzheimer's patients.
How similar studies have performed: Previous research has shown that targeting mitochondrial dysfunction and oxidative stress can yield promising results in Alzheimer's disease, suggesting that this approach may be effective.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Yan, Shi Fang — Columbia University Health Sciences
- Study coordinator: Yan, Shi Fang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.