Investigating the role of protein arginine methyltransferases in Alzheimer's disease
Official title: Protein Arginine Methyltransferases in Alzheimer's disease
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11081765 · Data updated 2026-11-12
This study is looking at how a specific protein might influence the progression of Alzheimer's disease in older women, and it aims to find out if blocking this protein can help improve brain health and memory.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $692,539 |
| NIH project number | 5R01AG081258-02 |
| Project ID | NIH-11081765 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly women, who are at risk for or diagnosed with Alzheimer's disease.
✕Less likely to help
Patients with early-stage Alzheimer's disease or those who do not have the specific risk factors being studied may not benefit from this research.
What this research studies
This research focuses on understanding how protein arginine methyltransferases, particularly protein arginine methyltransferase 4, affect the progression of Alzheimer's disease, especially in older women. The study will explore the relationship between these proteins and neurovascular health, brain metabolism, and cognitive functions such as learning and memory. By using a specific mouse model of Alzheimer's, researchers aim to determine how inhibiting this protein could potentially improve brain function and delay the onset of neurodegeneration. The findings could lead to new therapeutic strategies for managing Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow the progression of Alzheimer's disease and improve cognitive function in affected individuals.
How similar studies have gone: While the role of protein arginine methyltransferases in neurodegenerative diseases is an emerging field, similar studies have shown promising results in understanding their impact on brain health.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Lin, Hung Wen (Kevin) — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Lin, Hung Wen (Kevin)
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.