Investigating the role of Polycomb proteins in early mouse development
Genomic and functional analyses of Polycomb group proteins in mouse preimplantation development
This study is looking at how certain proteins help control gene activity during the early development of mice, which could give us important clues about how genes work and how they might be linked to diseases in humans.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11004979 on NIH RePORTER |
What this research studies
This research focuses on understanding how Polycomb group (PcG) proteins influence gene regulation during the early stages of mouse development. By utilizing advanced techniques for profiling chromatin dynamics, the study aims to uncover the mechanisms by which these proteins maintain epigenetic memory and regulate gene expression in preimplantation embryos. The research will explore the distinct roles of two complexes, PRC1 and PRC2, in modifying histones and their impact on chromatin structure. This could provide insights into developmental processes and potential implications for human diseases related to gene regulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the genetic and epigenetic factors influencing early development and related health conditions.
Not a fit: Patients with established developmental disorders that are not linked to epigenetic regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for addressing developmental disorders and diseases linked to gene regulation.
How similar studies have performed: Previous research has shown promising results in understanding chromatin dynamics and gene regulation, indicating that this approach has potential for significant findings.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Chen, Zhiyuan — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Chen, Zhiyuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.