Investigating the role of PI3 kinase in Myelodysplastic Syndrome
PI3 Kinase Inactivation in Myelodysplastic Syndrome
This study is looking at how certain changes in genes might affect blood cell production in older adults with Myelodysplastic Syndrome (MDS), and it hopes to find new ways to help improve treatment for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11112391 on NIH RePORTER |
What this research studies
This research focuses on Myelodysplastic Syndrome (MDS), a disorder that affects blood cell production, particularly in older adults. The study examines how mutations in RNA splicing factors and the PI3K/AKT signaling pathway contribute to the disease. By using mouse models, researchers aim to understand the mechanisms behind impaired blood cell differentiation and genomic instability in MDS. The goal is to explore potential therapeutic approaches that could improve patient outcomes by targeting these pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults diagnosed with Myelodysplastic Syndrome or those exhibiting symptoms related to blood cell deficiencies.
Not a fit: Patients with other forms of blood disorders or those who do not have Myelodysplastic Syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood cell production and overall health for patients with Myelodysplastic Syndrome.
How similar studies have performed: Previous research has shown promising results in targeting the PI3K/AKT pathway for blood disorders, indicating potential for success in this approach.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Gritsman, Kira — Albert Einstein College of Medicine
- Study coordinator: Gritsman, Kira
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.