Investigating the role of perineuronal nets in postoperative delirium in older adults
Perineuronal nets: a new player in postoperative delirium?
This study is looking at how special protective structures around brain cells might affect the chances of older adults experiencing confusion and memory problems after surgery, with the hope of finding new ways to help prevent these issues.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10869690 on NIH RePORTER |
What this research studies
This research focuses on understanding how perineuronal nets, which are protective structures around certain brain neurons, may influence the occurrence of postoperative delirium in older adults. Postoperative delirium is a serious condition that can affect memory and cognitive function after surgery, particularly in patients aged 65 and older. The study aims to explore the relationship between these nets and cognitive decline, potentially leading to new treatment strategies. By examining the biological mechanisms involved, the research seeks to identify ways to mitigate the risks associated with delirium following surgery.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above who are undergoing major surgery requiring anesthesia.
Not a fit: Patients who are younger than 65 years old or those not undergoing surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that prevent or treat postoperative delirium, improving recovery outcomes for older patients.
How similar studies have performed: While previous studies have explored related factors in delirium, the specific investigation of perineuronal nets is a novel approach that has not been extensively tested.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Lunardi, Nadia — University of Virginia
- Study coordinator: Lunardi, Nadia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.