Investigating the role of p53 protein in the cytoplasm
Official title: Function and regulation of cytoplasmic p53
Funded at Univ of North Carolina Chapel Hill · NIH-10931342 · Data updated 2026-11-12
This study is looking at how a protein called p53 works in the part of the cell outside the nucleus, which might help us understand how it affects cell death and metabolism, and it’s using specially modified mice to see how these changes could relate to cancer and other diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $331,674 |
| NIH project number | 5R01CA276414-02 |
| Project ID | NIH-10931342 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers that may be influenced by p53 activity or those with genetic alterations affecting p53 function.
✕Less likely to help
Patients with conditions unrelated to p53 or those who do not have any form of cancer may not benefit from this research.
What this research studies
This research focuses on understanding the functions of the p53 protein outside the nucleus, particularly in the cytoplasm, where it may play a role in regulating cell death and metabolism. The study involves creating a mouse model with a modified version of p53 to mimic changes found in bats, which may help clarify how p53 contributes to these processes in living organisms. By examining the interactions of cytoplasmic p53 with other proteins, the research aims to uncover new mechanisms that could influence cancer and other diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for cancers by targeting the cytoplasmic functions of p53.
How similar studies have gone: Previous research has shown promising results in understanding the roles of p53 in cancer, but this specific focus on cytoplasmic p53 is relatively novel.
Where this research is happening
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Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Marzluff, William F. — Univ of North Carolina Chapel Hill
- Study coordinator: Marzluff, William F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.