Investigating the role of p53 and DNA repair in breast cancer mortality differences
P53, DNA Repair Imbalance, and Immune Response in Breast Cancer Mortality Disparities
This study is looking at how certain proteins and DNA repair processes might explain why breast cancer affects different racial groups differently, especially focusing on African American women, to help improve survival rates.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11051164 on NIH RePORTER |
What this research studies
This research explores how the tumor suppressor protein p53 and various DNA repair mechanisms contribute to disparities in breast cancer mortality, particularly among different racial groups. By analyzing human tumor samples, the study aims to understand how mutations in DNA repair pathways affect cancer outcomes. The researchers will utilize advanced techniques to profile these mutations and their relationships with p53 function, focusing on the implications for African American women. This work seeks to uncover the biological factors that may lead to differences in breast cancer survival rates.
Who could benefit from this research
Good fit: Ideal candidates for this research include African American women diagnosed with breast cancer, as well as individuals with known mutations in DNA repair pathways.
Not a fit: Patients with breast cancer who do not belong to the populations being studied or those without relevant genetic mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for breast cancer, particularly for populations facing higher mortality rates.
How similar studies have performed: While there have been studies on p53 and DNA repair, this research is notable for its focus on racial disparities in breast cancer mortality, making it a novel approach.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Troester, Melissa a. — Univ of North Carolina Chapel Hill
- Study coordinator: Troester, Melissa a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.