Investigating the role of oxidative stress in neurodegeneration and heart changes.
Official title: Chemogenetic Neurovascular Oxidative Stress: Neurodegeneration and Cardiac Remodeling
Funded at Brigham and Women's Hospital · NIH-11021027 · Data updated 2026-11-12
This study is looking at how stress in our cells might lead to brain and heart problems, especially in people with Alzheimer's and similar conditions, by using special mice that can help scientists see what happens when certain chemicals are changed in specific cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | February 2, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $698,827 |
| NIH project number | 5R01NS131182-02 |
| Project ID | NIH-11021027 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias, particularly those experiencing cognitive impairment and cardiovascular issues.
✕Less likely to help
Patients with neurodegenerative conditions unrelated to oxidative stress or those without cognitive impairment may not benefit from this research.
What this research studies
This research focuses on understanding how oxidative stress contributes to neurodegeneration and cardiac remodeling, particularly in conditions like Alzheimer's disease and related dementias. Using a unique chemogenetic approach, researchers will manipulate reactive oxygen species in specific cells to observe their effects on the nervous system and heart. The study involves creating genetically modified mice that can produce hydrogen peroxide in targeted cells, allowing for real-time observation of neurodegenerative processes and cardiac changes. By examining these effects, the research aims to uncover potential pathways for intervention in neurodegenerative diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating neurodegenerative diseases and associated cardiac issues.
How similar studies have gone: Previous research has shown promising results in targeting oxidative stress in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Michel, Thomas — Brigham and Women's Hospital
- Study coordinator: Michel, Thomas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.