Investigating the role of Oncostatin M in pancreatic cancer
Oncostatin M Receptor in Pancreatic Adenocarcinoma
This study is looking at how a molecule called Oncostatin M affects pancreatic cancer cells and their surroundings, with the goal of finding new ways to help patients with this tough-to-treat cancer live longer and have better treatment options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Portland VA Medical Center NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10807826 on NIH RePORTER |
What this research studies
This research focuses on pancreatic ductal adenocarcinoma (PDAC), a highly aggressive form of pancreatic cancer with a very low survival rate. The study aims to understand how Oncostatin M (OSM), a signaling molecule, influences the tumor environment and promotes cancer cell survival and resistance to treatment. By examining the interactions between OSM and various cell types in the tumor microenvironment, the research seeks to identify new therapeutic targets that could improve treatment outcomes for patients with PDAC. The approach includes laboratory studies using cell lines and analysis of tumor samples to uncover the mechanisms by which OSM contributes to cancer progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults diagnosed with pancreatic ductal adenocarcinoma.
Not a fit: Patients with other types of cancer or those who are not diagnosed with pancreatic cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that improve survival rates for patients with pancreatic cancer.
How similar studies have performed: While there has been significant research on pancreatic cancer, the specific role of Oncostatin M in this context is still being explored, making this approach relatively novel.
Where this research is happening
Portland, United States
- Portland VA Medical Center — Portland, United States (Active)
Researchers
- Principal investigator: Zimmers, Teresa a — Portland VA Medical Center
- Study coordinator: Zimmers, Teresa a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.