Investigating the role of Oncostatin M in pancreatic cancer
Official title: Oncostatin M Receptor in Pancreatic Adenocarcinoma
Funded at Portland VA Medical Center · NIH-10807826 · Data updated 2026-11-12
This study is looking at how a molecule called Oncostatin M affects pancreatic cancer cells and their surroundings, with the goal of finding new ways to help patients with this tough-to-treat cancer live longer and have better treatment options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Portland VA Medical Center NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| NIH project number | 1I01BX006305-01A1 |
| Project ID | NIH-10807826 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults diagnosed with pancreatic ductal adenocarcinoma.
✕Less likely to help
Patients with other types of cancer or those who are not diagnosed with pancreatic cancer may not benefit from this research.
What this research studies
This research focuses on pancreatic ductal adenocarcinoma (PDAC), a highly aggressive form of pancreatic cancer with a very low survival rate. The study aims to understand how Oncostatin M (OSM), a signaling molecule, influences the tumor environment and promotes cancer cell survival and resistance to treatment. By examining the interactions between OSM and various cell types in the tumor microenvironment, the research seeks to identify new therapeutic targets that could improve treatment outcomes for patients with PDAC. The approach includes laboratory studies using cell lines and analysis of tumor samples to uncover the mechanisms by which OSM contributes to cancer progression.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that improve survival rates for patients with pancreatic cancer.
How similar studies have gone: While there has been significant research on pancreatic cancer, the specific role of Oncostatin M in this context is still being explored, making this approach relatively novel.
Where this research is happening
-
Portland VA Medical Center
Portland, United States Active
Researchers
- Principal investigator: Zimmers, Teresa a — Portland VA Medical Center
- Study coordinator: Zimmers, Teresa a
Related research
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Oncostatin M Receptor in Pancreatic Cancer
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-
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Turning inflammatory scar cells in the pancreas into helpers to improve treatment response
This project will try to change inflammatory, scar-forming cells around pancreatic tumors so treatments and the immune system can work better for people with pancreatic ductal adenocarcinoma.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.