Investigating the role of Nrf2 and immune cells in lung cancer
Nrf2, immune cells and lung cancer
This study is looking at how a protein called Nrf2 and immune cells work together in lung cancer, especially for former smokers, to see if certain foods can help lower cancer risk and improve treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11043643 on NIH RePORTER |
What this research studies
This research focuses on understanding how the Nrf2 protein and immune cells interact in the context of lung cancer. It aims to explore the effects of dietary components that activate the Nrf2 pathway, which may help reduce cancer risk and improve outcomes for patients, particularly former smokers who are at higher risk. The study involves examining immune responses in mouse models to identify potential therapeutic targets and strategies for early intervention. By analyzing changes in immune cell populations and gene expression, the research seeks to uncover mechanisms that could lead to better treatment options for lung cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are former smokers and individuals at elevated risk for lung cancer.
Not a fit: Patients with advanced lung cancer who are not eligible for early intervention may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new preventive strategies and treatments for lung cancer, particularly for high-risk individuals.
How similar studies have performed: Previous research has shown promising results in targeting the Nrf2 pathway for cancer prevention, indicating potential for success in this approach.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Mendes Leal, Ana Sofia — Indiana University Indianapolis
- Study coordinator: Mendes Leal, Ana Sofia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.