Investigating the role of NOX4 in heart rhythm disorders in older adults
Targeting NOX4-dependent mitochondrial dysfunction, autophagy and defective calcium handling in AF
This study is looking at how a certain enzyme called NOX4 affects heart rhythm problems, like atrial fibrillation, especially in people over 65, using special animal models to find out how it impacts heart function and could help us discover new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11011446 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific enzyme, NOX4, contributes to atrial fibrillation (AF), a common heart rhythm disorder in individuals over 65. By using advanced animal models, including genetically modified zebrafish and mice, the study aims to explore the mechanisms by which NOX4 affects heart function and leads to AF. The researchers will analyze the impact of mitochondrial dysfunction and autophagy on the development of AF, providing insights that could lead to new treatment strategies for this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above who are experiencing or at risk for atrial fibrillation.
Not a fit: Patients under the age of 65 or those without any history of heart rhythm disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for atrial fibrillation, potentially reducing the risk of serious complications like stroke and heart failure in older patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of oxidative stress in heart conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Cai, Hua Linda — University of California Los Angeles
- Study coordinator: Cai, Hua Linda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.