Investigating the role of noncoding RNAs in acute myeloid leukemia
Official title: Biology and Targeting of noncoding RNAs in AML
Funded at University of Utah · NIH-10932390 · Data updated 2026-11-12
This study is looking at how certain molecules called long noncoding RNAs might help acute myeloid leukemia (AML) cells grow, with the hope of finding new ways to treat patients with this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | February 24, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $352,275 |
| NIH project number | 5R01CA240612-05 |
| Project ID | NIH-10932390 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with acute myeloid leukemia, particularly those with cytogenetically normal AML and mutations in the NPM1 gene.
✕Less likely to help
Patients with other types of leukemia or those who do not have the specific genetic mutations being studied may not benefit from this research.
What this research studies
This research focuses on understanding the biology of acute myeloid leukemia (AML) by exploring the role of long noncoding RNAs (lncRNAs) in the disease. It aims to identify how these lncRNAs, particularly HOXB-AS3, contribute to the proliferation of AML cells and their potential as therapeutic targets. The study involves both in vitro experiments with AML cell lines and in vivo experiments using patient-derived xenograft models to assess the effects of silencing specific lncRNAs on cancer progression and patient survival. By uncovering these mechanisms, the research seeks to pave the way for new treatment strategies for AML patients.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapies that improve survival rates for patients with acute myeloid leukemia.
How similar studies have gone: While the role of lncRNAs in solid tumors has been explored, this research is pioneering in its focus on their function in acute myeloid leukemia, making it a novel approach.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Garzon, Ramiro — University of Utah
- Study coordinator: Garzon, Ramiro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.