Investigating the role of non-coding RNAs in heart development and disease
lncRNA Function and Mechanisms during Cardiac Development and Disease
This study is looking at how certain genetic materials called long non-coding RNAs might affect heart development and heart diseases, especially in people with ischemic cardiomyopathy, to find new ways to help improve heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11018502 on NIH RePORTER |
What this research studies
This research focuses on understanding how long non-coding RNAs (lncRNAs) influence heart development and the progression of heart diseases. By analyzing genetic material from patients with ischemic cardiomyopathy, the study aims to identify specific lncRNAs that may play critical roles in heart function and disease mechanisms. The researchers will employ advanced techniques, including RNA sequencing, to explore the biological activities of these lncRNAs and their potential as therapeutic targets. This could lead to new insights into the genetic factors contributing to cardiovascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with ischemic cardiomyopathy or other forms of heart disease.
Not a fit: Patients with non-cardiovascular diseases or those without any heart-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapies targeting lncRNAs, improving treatment options for patients with heart disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of lncRNAs in various diseases, suggesting that this approach could yield valuable insights in the context of heart disease as well.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Wang, Da-Zhi — University of South Florida
- Study coordinator: Wang, Da-Zhi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.