Investigating the role of non-coding RNAs in heart development and disease
Official title: lncRNA Function and Mechanisms during Cardiac Development and Disease
Funded at University of South Florida · NIH-11018502 · Data updated 2026-11-12
This study is looking at how certain genetic materials called long non-coding RNAs might affect heart development and heart diseases, especially in people with ischemic cardiomyopathy, to find new ways to help improve heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $504,632 |
| NIH project number | 5R01HL165794-03 |
| Project ID | NIH-11018502 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with ischemic cardiomyopathy or other forms of heart disease.
✕Less likely to help
Patients with non-cardiovascular diseases or those without any heart-related conditions may not benefit from this research.
What this research studies
This research focuses on understanding how long non-coding RNAs (lncRNAs) influence heart development and the progression of heart diseases. By analyzing genetic material from patients with ischemic cardiomyopathy, the study aims to identify specific lncRNAs that may play critical roles in heart function and disease mechanisms. The researchers will employ advanced techniques, including RNA sequencing, to explore the biological activities of these lncRNAs and their potential as therapeutic targets. This could lead to new insights into the genetic factors contributing to cardiovascular diseases.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapies targeting lncRNAs, improving treatment options for patients with heart disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of lncRNAs in various diseases, suggesting that this approach could yield valuable insights in the context of heart disease as well.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Wang, Da-Zhi — University of South Florida
- Study coordinator: Wang, Da-Zhi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.