Investigating the role of non-B DNA structures in genome evolution
Official title: Non-B DNA and Genome Evolution
Funded at Pennsylvania State University, the · NIH-11005317 · Data updated 2026-11-12
This study is looking at how unusual shapes of DNA can affect how our genes change and evolve, which could help us understand important processes in our cells and their impact on our health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $777,653 |
| NIH project number | 5R35GM151945-02 |
| Project ID | NIH-11005317 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic conditions or diseases linked to genome variations, such as certain cancers or neurodegenerative disorders.
✕Less likely to help
Patients with conditions unrelated to genetic variations or those not involving genome evolution may not benefit from this research.
What this research studies
This research explores how different structures of DNA, specifically non-canonical forms, influence genome evolution. The Makova Laboratory employs both experimental and computational methods to understand the mechanisms behind genome variation and architecture. By focusing on non-B DNA structures, such as G-quadruplexes and Z-DNA, the research aims to uncover their roles during critical cellular processes like differentiation and stress responses. This work could provide insights into the evolutionary significance of these DNA forms and their impact on human health.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic variations that influence diseases, potentially improving diagnosis and treatment strategies.
How similar studies have gone: Previous research has shown promising results in understanding the implications of non-B DNA structures in various biological processes, indicating that this approach has potential for significant discoveries.
Where this research is happening
-
Pennsylvania State University, the
University Park, United States Active
Researchers
- Principal investigator: Makova, Kateryna — Pennsylvania State University, the
- Study coordinator: Makova, Kateryna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.