Investigating the role of nitroxyl in bacteria related to anthrax
Official title: Chemical Biology of Nitroxyl (HNO) in Bacillus Subtilis
Funded at Wake Forest University · NIH-10730746 · Data updated 2026-11-12
This study is looking at how some bacteria, like those that cause anthrax, use sulfur to grow and survive, and it hopes to find new ways to create antibiotics by understanding these processes better.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $407,044 |
| NIH project number | 1R15GM151698-01 |
| Project ID | NIH-10730746 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for infections caused by antibiotic-resistant bacteria, particularly those related to anthrax.
✕Less likely to help
Patients with infections that are not caused by Gram-positive bacteria or those who do not have antibiotic-resistant infections may not benefit from this research.
What this research studies
This research explores how certain bacteria, including those that cause anthrax, use sulfur in their metabolic processes. It focuses on the chemical interactions between nitroxyl and other reactive species that are crucial for bacterial growth and survival. By studying these interactions in a model organism, Bacillus subtilis, the research aims to uncover new strategies for developing antibiotics. The methodology includes in vitro experiments and analysis of bacterial behavior under different chemical conditions.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that are effective against resistant bacterial infections.
How similar studies have gone: While the specific approach of studying nitroxyl's role in bacterial physiology is novel, similar research has shown promise in understanding bacterial resistance mechanisms.
Where this research is happening
-
Wake Forest University
Winston-Salem, United States Active
Researchers
- Principal investigator: King, S Bruce — Wake Forest University
- Study coordinator: King, S Bruce
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.