Investigating the role of neutrophil traps in neonatal inflammation and infection
NETs: Protection or Harm in Neonatal Inflammation and Infection
This study is looking at how certain traps made by immune cells can cause problems in newborns with infections, and it’s testing new treatments that might help reduce this damage and improve their chances of recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11047337 on NIH RePORTER |
What this research studies
This research explores how neutrophil extracellular traps (NETs) contribute to inflammation and injury in newborns suffering from infections. The study utilizes novel peptides that inhibit NET formation, aiming to reduce inflammatory damage and improve survival rates in experimental models of neonatal sepsis. By examining the mechanisms behind these peptides and their interaction with specific proteins on neutrophils, the research seeks to uncover new therapeutic targets for managing severe infections in neonates.
Who could benefit from this research
Good fit: Ideal candidates for this research are neonates and infants who are experiencing severe infections or sepsis.
Not a fit: Patients who are older than 21 years or those without severe infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce inflammation and improve survival rates in newborns with infections.
How similar studies have performed: Previous research has shown promising results with similar approaches in managing inflammation and infection, suggesting potential for success in this novel application.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Yost, Christian Con — University of Utah
- Study coordinator: Yost, Christian Con
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.