Investigating the role of neurogranin in traumatic brain injury
Neurogranin and Traumatic Brain Injury
This study is looking at a protein called neurogranin to see how it might affect thinking problems after a traumatic brain injury, especially in military personnel, and aims to find new ways to help improve brain function for those dealing with these challenges.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10948917 on NIH RePORTER |
What this research studies
This research focuses on understanding how neurogranin, a protein involved in synaptic function, may play a role in the cognitive impairments associated with traumatic brain injury (TBI), particularly in military personnel. The study aims to explore the cellular mechanisms underlying TBI-related cognitive deficits using animal models that mimic the effects of TBI. By examining synaptic strength and plasticity, the research seeks to identify potential therapeutic targets that could lead to new treatments for TBI. The ultimate goal is to develop pharmacotherapies that can improve cognitive function in individuals suffering from the long-term effects of TBI.
Who could benefit from this research
Good fit: Ideal candidates for this research include military personnel who have experienced traumatic brain injuries, particularly those with persistent cognitive impairments.
Not a fit: Patients who have not experienced traumatic brain injuries or those with cognitive impairments due to other causes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and quality of life for individuals affected by traumatic brain injury.
How similar studies have performed: Previous research has shown promise in using animal models to investigate cognitive impairments related to TBI, indicating that this approach may yield valuable insights.
Where this research is happening
Pittsburgh, United States
- Veterans Health Administration — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Dixon, C Edward — Veterans Health Administration
- Study coordinator: Dixon, C Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.