Investigating the role of NEDD4 in the development of the right ventricle of the heart
NEDD4 in right ventricular development
This study is looking at how changes in a specific protein can affect the growth of the right side of the heart in mice, which might help us understand heart problems in babies and find new ways to treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10910884 on NIH RePORTER |
What this research studies
This research focuses on understanding how abnormalities in the development of the right ventricle (RV) can lead to congenital heart disease (CHD). By studying mice with a specific genetic alteration that affects the NEDD4 protein, researchers aim to uncover the molecular pathways that contribute to RV growth and expansion during critical developmental stages. The study employs advanced techniques such as proteomics and electron microscopy to analyze the effects of NEDD4 deletion on heart tissue. This research could provide insights into the mechanisms behind heart malformations and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital heart disease, particularly those with right ventricular abnormalities.
Not a fit: Patients with heart conditions unrelated to right ventricular development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating congenital heart defects in patients.
How similar studies have performed: Other research has shown success in understanding cardiac development through genetic studies, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Fang, Xi — University of California, San Diego
- Study coordinator: Fang, Xi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.