Investigating the role of NAD+ in heart failure
Mechanistic Studies of NAD+/NADH in Human Heart Failure
This study is looking at how two important molecules, NAD+ and NADH, impact heart health in people with heart failure, and it aims to find ways to boost NAD+ levels to help improve heart function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10693087 on NIH RePORTER |
What this research studies
This research explores how the balance of NAD+ and NADH, two important molecules in energy metabolism, affects heart function in patients with heart failure. By examining the mechanisms behind mitochondrial dysfunction, the study aims to identify potential therapies that could restore NAD+ levels and improve heart health. The approach includes both laboratory studies and clinical trials involving human participants to assess the effects of NAD+ supplementation on heart function and metabolism.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure who may benefit from new therapeutic approaches targeting NAD+ levels.
Not a fit: Patients with heart failure who are not responsive to metabolic interventions or those with advanced stages of heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and quality of life for patients with heart failure.
How similar studies have performed: Previous studies have shown promising results with NAD+ supplementation in animal models, suggesting potential for success in human applications.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: O'brien, Kevin D. — University of Washington
- Study coordinator: O'brien, Kevin D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.