Investigating the role of Myosin 18 in muscle function
Myosin 18 and its role in skeletal muscle
This study is looking at two important proteins, Myosin 18A and Myosin 18B, to understand how they help build muscle fibers and how changes in these proteins might lead to muscle diseases, so we can learn more about keeping muscles healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10817064 on NIH RePORTER |
What this research studies
This research focuses on understanding the structure and function of Myosin 18, a protein that plays a crucial role in the formation of muscle fibers. The project aims to explore how Myosin 18B is essential for creating sarcomeres, the basic units of muscle contraction, while Myosin 18A is involved in various cellular processes across different cell types. By studying these proteins, researchers hope to uncover their mechanisms and how mutations affecting them can lead to muscle diseases. This work involves advanced techniques in cell culture and molecular biology to analyze protein interactions and functions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic mutations affecting Myosin 18 or those diagnosed with myopathies related to muscle function.
Not a fit: Patients with muscle disorders not linked to Myosin 18 mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into muscle disorders and potential therapeutic targets for treatment.
How similar studies have performed: Previous research has shown promising results in understanding the roles of unconventional myosins in muscle function, suggesting that this approach could yield valuable insights.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Sweeney, H Lee — University of Florida
- Study coordinator: Sweeney, H Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.