Investigating the role of mTORC1 and WNT signaling in a rare lung disease.
mTORC1 and WNT in lung mesenchyme
This study is looking at Lymphangioleiomyomatosis (LAM), a rare lung disease, to better understand what causes it by comparing lung tissue from LAM patients to healthy individuals, and it aims to find new ways to treat the disease while also considering how age and gender might affect it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10875375 on NIH RePORTER |
What this research studies
This research focuses on Lymphangioleiomyomatosis (LAM), a rare and severe lung disease caused by mutations in specific genes. The study aims to understand the origins of LAM cells by comparing lung tissue from LAM patients to healthy controls using advanced single-cell RNA sequencing techniques. By identifying unique cell types and gene expression patterns associated with LAM, the researchers hope to uncover the mechanisms driving the disease and explore potential therapeutic targets. The research also examines how age and sex influence the disease's progression and characteristics.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Lymphangioleiomyomatosis (LAM), particularly those with specific genetic mutations.
Not a fit: Patients with other lung diseases or those not diagnosed with LAM may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for patients suffering from LAM and related lung conditions.
How similar studies have performed: While the specific approach of this research is novel, similar studies have shown promise in understanding other lung diseases through genetic and cellular analysis.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Krymskaya, Vera P — University of Pennsylvania
- Study coordinator: Krymskaya, Vera P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.