Investigating the role of MK2 in pulmonary hypertension
MK2 and pulmonary hypertension
This study is looking at how a protein called MK2 influences pulmonary arterial hypertension (PAH), a condition that raises blood pressure in the lungs, to find new ways to help manage the symptoms and improve treatment options for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10850550 on NIH RePORTER |
What this research studies
This research focuses on understanding how the protein MK2 affects the development of pulmonary arterial hypertension (PAH), a serious condition that causes high blood pressure in the lungs. The study examines how MK2 is regulated by factors related to low oxygen levels and how its loss contributes to the disease by preventing cell death and promoting cell growth in the blood vessels of the lungs. By exploring these mechanisms, the research aims to uncover potential new targets for treatment that could help manage or alleviate the symptoms of PAH.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension.
Not a fit: Patients with other forms of pulmonary hypertension or those without a diagnosis of pulmonary arterial hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating pulmonary arterial hypertension, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in other vascular diseases, suggesting potential for success in this area as well.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Shimoda, Larissa a. — Johns Hopkins University
- Study coordinator: Shimoda, Larissa a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.