Investigating the role of mitochondrial RNA in brain aging and Alzheimer's disease
Official title: Mitochondria-derived dsRNA in brain aging and Alzheimer's disease
Funded at Colorado State University · NIH-11140291 · Data updated 2026-11-12
This study is looking at how certain RNA from our cells' energy factories, called mitochondria, might play a role in brain inflammation as we age and in Alzheimer's disease, with the hope of finding new ways to help improve brain health for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $76,756 |
| NIH project number | 5F32AG087636-02 |
| Project ID | NIH-11140291 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older, particularly those experiencing cognitive decline or at risk for Alzheimer's disease.
✕Less likely to help
Patients under the age of 65 or those without cognitive impairment may not receive direct benefits from this research.
What this research studies
This research explores how double-stranded RNA derived from mitochondria may contribute to neuroinflammation associated with aging and Alzheimer's disease. The study focuses on understanding the mechanisms by which mitochondrial dysfunction leads to the formation of this RNA and its potential effects on brain health. By examining these processes, the research aims to uncover new insights into the relationship between aging, neurodegeneration, and Alzheimer's pathology. Patients may benefit from a deeper understanding of how these factors interact, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for Alzheimer's disease and age-related cognitive decline.
How similar studies have gone: While the role of mitochondrial dysfunction in aging and neurodegeneration is established, the specific investigation of mitochondrial-derived RNA in this context is relatively novel and has not been extensively studied.
Where this research is happening
-
Colorado State University
Fort Collins, United States Active
Researchers
- Principal investigator: Doser, Rachel — Colorado State University
- Study coordinator: Doser, Rachel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.